发明公开
- 专利标题： MODULATORS OF PROTEIN TYROSINE PHOSPHATASES
- 专利标题（中）： 蛋白酪氨酸磷酸酶的调节剂
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申请号： EP99907336.4申请日： 1999-03-12
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公开(公告)号： EP1080068A1公开(公告)日： 2001-03-07
- 发明人: RICHTER, Lutz Stefan , ANDERSEN, Henrik Sune , VAGNER, Josef , JEPPESEN, Claus, Becker , MOELLER, Niels P H , BRANNER, Sven , JEPPESEN, Lone , OLSEN, Ole Hvilsted , IVERSEN, Lars Fogh , HOLSWORTH, Daniel Dale , AXE, Frank Urban , GE, Yu , JONES, Todd, Kevin , RIPKA, William Charles , UYEDA, Roy Teruyuki , SU, Jing , BAKIR, Farid , JUDGE, Luke Milburn
- 申请人： Novo Nordisk A/S , Ontogen Corporation
- 申请人地址： Corporate Patents,Novo Allé 2880 Bagsvaerd DK
- 专利权人： Novo Nordisk A/S,Ontogen Corporation
- 当前专利权人： Novo Nordisk A/S,Ontogen Corporation
- 当前专利权人地址： Corporate Patents,Novo Allé 2880 Bagsvaerd DK
- 代理机构： Stephensen, Birgitte Borregaard (DK)
- 优先权： DK35098 19980312; DK34598 19980312; DK34398 19980312; DK34298 19980312; DK34498 19980312; DK34798 19980312; DK34698 19980312; DK34898 19980312; DK47998 19980403; DK47298 19980403; DK47398 19980403; DK47898 19980403; DK47598 19980403; DK47498 19980403; DK47698 19980403; DK48098 19980403; US82912P 19980424; DK66798 19980515; US88115P 19980605; DK93998 19980715; DK94098 19980715; DK93898 19980715; DK138598 19981028; DK156198 19981126; DK161298 19981207
- 国际公布： WO9946237 19990916
- 主分类号： C07C235/84
- IPC分类号： C07C235/84
摘要：
The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases, PTPs) such as PTP1B, TC-PTP, CD45, SHP-1, SHP-2, PTPα, PTPε, PTPν, PTPδ, PTPσ, PTPz, PTPβ, PTPD1, PTPD2, PTPH1, PTP-MEG1, PTP-LAR, and HePTP. These compounds are indicated in the management or treatment of a broad range of diseases such as autoimmune diseases, acute and chronic inflammation, osteoporosis, various forms of cancer and malignant diseases, and type I diabetes and type II diabetes.
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