发明公开
- 专利标题： CORIN, A SERINE PROTEASE
- 专利标题（中）： CORIN，丝氨酸蛋白酶
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申请号： EP99927888.0申请日： 1999-06-04
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公开(公告)号： EP1084259A1公开(公告)日： 2001-03-21
- 发明人: MORSER, Michael, John , WU, Qingyu , YAN, Wei
- 申请人： Schering Aktiengesellschaft
- 申请人地址： Müllerstrasse 178 13353 Berlin DE
- 专利权人： Schering Aktiengesellschaft
- 当前专利权人： Schering Aktiengesellschaft
- 当前专利权人地址： Müllerstrasse 178 13353 Berlin DE
- 优先权： US92029 19980605; US314967 19990520
- 国际公布： WO9964608 19991216
- 主分类号： C12N15/57
- IPC分类号： C12N15/57 ; C12N9/64 ; C12N5/10 ; C12Q1/37 ; C07K16/40
摘要：
The present invention relates to a corin polypeptide which contains one or more frizzled corin and possesses various activities, including, e.g., serin protease activity and a pro-ANF converting activity, LDLR, SRCR repeats, serine protease catalytic domains such as human and mouse corin. The invention further relates to methods of using such nucleic acids and polypeptides in therapeutics, diagnostics, and research. For example, the nucleic acids and polypeptides of corin can be utilized in methods to identify modulators of its activity, in animal models to mimic human disease, and to treat kidney, cardiovascular, and other conditions in which corin is involved.
公开/授权文献
- EP1084259B1 CORIN, A SERINE PROTEASE 公开/授权日：2008-05-28
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