发明公开
- 专利标题： MUSCARINIC RECEPTOR ANTAGONISTS
- 专利标题（中）： MUSKARINREZEPTORANTAGONISTEN
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申请号： EP99928444.1申请日： 1999-06-07
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公开(公告)号： EP1086066A1公开(公告)日： 2001-03-28
- 发明人: MAMMEN, Mathai , OARE, David , GRIFFIN, John, H. , AGGEN, James
- 申请人： Advanced Medicine, Inc.
- 申请人地址： 901 Gateway Boulevard South San Francisco, CA 94080 US
- 专利权人： Advanced Medicine, Inc.
- 当前专利权人： Advanced Medicine, Inc.
- 当前专利权人地址： 901 Gateway Boulevard South San Francisco, CA 94080 US
- 代理机构： Adams, Nicola
- 优先权： US88466P 19980608; US92938P 19980715; US120287P 19990216
- 国际公布： WO9964043 19991216
- 主分类号： C07B61/00
- IPC分类号： C07B61/00 ; A61K38/00 ; A61K39/00 ; A61K39/44 ; A61K39/395 ; A61K51/00 ; G01N33/53 ; G01N33/543 ; G01N33/566
摘要：
Disclosed are multibinding compounds which are muscarinic receptor antagonists. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a muscarinic receptor antagonist or an allosteric modulator provided that at least one of said ligand is a muscarinic receptor antagonist. The multibinding compounds of this invention are useful in the treatment and prevention of diseases such as chronic obstructive pulmonary disease, chronic bronchitis, irritable bowel syndrome, urinary incontinence, and the like.
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