发明公开
EP1086082A1 ARYLSUBSTITUTED OLEFINIC AMINES AND THEIR USE AS CHOLINERGIC RECEPTORS AGONISTS
有权
芳基取代的烯胺和它们的用途AS和胆碱能受体激动剂
- 专利标题： ARYLSUBSTITUTED OLEFINIC AMINES AND THEIR USE AS CHOLINERGIC RECEPTORS AGONISTS
- 专利标题（中）： 芳基取代的烯胺和它们的用途AS和胆碱能受体激动剂
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申请号： EP99926152.2申请日： 1999-06-03
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公开(公告)号： EP1086082A1公开(公告)日： 2001-03-28
- 发明人: CALDWELL, William, Scott , DULL, Gary, Maurice , BHATTI, Balwinder, Singh , HADIMANI, Srishailkumar, B. , PARK, Haeil , WAGNER, Jared, Miller , CROOKS, Peter, Anthony , LIPPIELLO, Patrick, Michael , BENCHERIF, Merouane
- 申请人： R.J. REYNOLDS TOBACCO COMPANY
- 申请人地址： Bowman Gray Technical Center,950 Reynolds Boulevard,P.O. Box 1487 Winston-Salem, NC 27102-1487 US
- 专利权人： R.J. REYNOLDS TOBACCO COMPANY
- 当前专利权人： R.J. REYNOLDS TOBACCO COMPANY
- 当前专利权人地址： Bowman Gray Technical Center,950 Reynolds Boulevard,P.O. Box 1487 Winston-Salem, NC 27102-1487 US
- 代理机构： Horner, Martin Grenville
- 优先权： US98285 19980616; US98133 19980616
- 国际公布： WO9965876 19991223
- 主分类号： C07D213/38
- IPC分类号： C07D213/38 ; C07D213/62 ; C07D213/61 ; C07D213/64 ; C07D239/26 ; A61K31/44
摘要：
Compounds incorporating aryl substituted olefinic amine are provided. Representative compounds are (4E)-N-methyl-5- (3-pyridyl) -4-penten-2-amine, (4E) -N-methyl-5- (5-pyrimidinyl) -4-penten-2-amine, (4E)-N-methyl-5-( 5-methoxy-3-pyridyl) -4-penten-2-amine, (4E)-N- methyl-5- (6-amino-5-methyl -3-pyridyl)-4-penten -2-amine, (2R)-(4E) -N-methyl-5-(3-pyridyl) -4-penten-2-amine, (2R)-(4E)-N- methyl-5-(5- isopropoxy-3-pyridyl) -4-penten-2-amine, (4E)-N-methyl -5-(5-bromo-3-pyridyl) -4-penten-2-amine, (4E)-N-methyl -5-(5-ethoxy-3- pyridyl)-4-penten- 2-amine, (2S)-(4E)-N- methyl-5-(3-pyridyl) -4-penten-2-amine, (4E)-N-methyl -5-(5-isopropoxy-3- pyridyl)-4- penten-2-amine and (2S)-(4E)-N-methyl -5-(5-isopropoxy -3-pyridyl) -4-penten-2-amine.
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