发明公开
EP1086207A1 NOVEL METHODS AND INTERFERON DEFICIENT SUBSTRATES FOR THE PROPAGATION OF VIRUSES
有权
新的方法和干扰素缺陷的底物，病毒的传播
- 专利标题： NOVEL METHODS AND INTERFERON DEFICIENT SUBSTRATES FOR THE PROPAGATION OF VIRUSES
- 专利标题（中）： 新的方法和干扰素缺陷的底物，病毒的传播
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申请号： EP99927443.4申请日： 1999-06-11
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公开(公告)号： EP1086207A1公开(公告)日： 2001-03-28
- 发明人: PALESE, Peter , GARCIA-SASTRE, Adolfo , O'NEIL, Robert
- 申请人： MOUNT SINAI SCHOOL OF MEDICINEOF THE CITY UNIVERSITY OF NEW YORK
- 申请人地址： One Gustave L. Levy Place New York, NY 10029-6574 US
- 专利权人： MOUNT SINAI SCHOOL OF MEDICINEOF THE CITY UNIVERSITY OF NEW YORK
- 当前专利权人： MOUNT SINAI SCHOOL OF MEDICINEOF THE CITY UNIVERSITY OF NEW YORK
- 当前专利权人地址： One Gustave L. Levy Place New York, NY 10029-6574 US
- 代理机构： Schüssler, Andrea, Dr.
- 优先权： US89103P 19980612; US108832P 19981118; US117683P 19990129
- 国际公布： WO9964570 19991216
- 主分类号： C12N7/00
- IPC分类号： C12N7/00 ; A61K39/12
摘要：
The present invention relates, in general, to attenuated negative-strand RNA viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. The invention also relates to the development and use of IFN-deficient systems for selection of such attenuated viruses. In particular, the invention relates to attenuated influenza viruses having modifications to the NS1 gene that diminish or eliminate the ability of the NS1 gene product to antagonize the cellular IFN response. The mutant viruses replicate in vivo but demonstrate reduced pathogenicity, and therefore are well suited for live virus vaccines, and pharmaceutical formulations.
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