A process for preparing a molded article that includes: (a) bringing a moldable material (10) and an open molding tool (16) comprising a molding surface into line contact with each other to imprint a microfluid processing architecture pattern onto the moldable material (10) and thereby form a molded article; and (b) separating the molded article from said molding surface. The invention also features various microfluid processing architecture-bearing, polymeric articles.