发明公开
EP1087937A1 CYCLIC HYDROXAMIC ACIDS AS METALLOPROTEINASE INHIBITORS
审中-公开
CYCLISCHEHYDROXAMSÄURENALS METROOPROTEINASE-INHIBITOREN
- 专利标题： CYCLIC HYDROXAMIC ACIDS AS METALLOPROTEINASE INHIBITORS
- 专利标题（中）： CYCLISCHEHYDROXAMSÄURENALS METROOPROTEINASE-INHIBITOREN
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申请号： EP99930371.2申请日： 1999-06-17
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公开(公告)号： EP1087937A1公开(公告)日： 2001-04-04
- 发明人: XUE, Chu-Baio , DECICCO, Carl, P. , HE, Xiaohua
- 申请人： Du Pont Pharmaceuticals Company
- 申请人地址： 974 Centre Road, WR-1st 18 Wilmington, DE 19807 US
- 专利权人： Du Pont Pharmaceuticals Company
- 当前专利权人： Du Pont Pharmaceuticals Company
- 当前专利权人地址： 974 Centre Road, WR-1st 18 Wilmington, DE 19807 US
- 代理机构： Beacham, Annabel Rose
- 优先权： US89557P 19980617; US127599P 19990402
- 国际公布： WO9965867 19991223
- 主分类号： C07C259/08
- IPC分类号： C07C259/08 ; C07D211/16 ; A61K31/47 ; C07D211/22 ; C07D213/30 ; C07D215/22 ; C07D213/40 ; C07D215/20 ; C07D401/12 ; C07D211/60 ; C07D405/14 ; C07D417/14 ; C07D401/14 ; C07D409/14 ; A61K31/445
摘要：
The present application describes novel cyclic hydroxamic acids of formula (I): or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms selected from O, N, NRa and S(O)¿p?, and 0-1 carbonyl groups and the other variables are defined in the present specification, which are useful as metalloprotease inhibitors.
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