- 专利标题: ARYLALKANOYLPYRIDAZINE
- 专利标题(英): Aryl alkanoylpyridazines
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申请号: EP99939760.7申请日: 1999-05-07
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公开(公告)号: EP1087946B1公开(公告)日: 2007-01-10
- 发明人: JONAS, Rochus , WOLF, Michael , KLUXEN, Franz-Werner
- 申请人: Merck Patent GmbH
- 申请人地址: Frankfurter Strasse 250 64293 Darmstadt DE
- 专利权人: Merck Patent GmbH
- 当前专利权人: Merck Patent GmbH
- 当前专利权人地址: Frankfurter Strasse 250 64293 Darmstadt DE
- 代理机构: Isenbruck, Günter
- 优先权: DE19826841 19980616
- 国际公布: WO1999065880 19991223
- 主分类号: C07D237/04
- IPC分类号: C07D237/04 ; C07D405/04 ; A61K31/50
摘要:
The invention relates to aryl alkanoylpyridazine derivatives of the formula (I) and their physiologically compatible salts and solvates, where R1, R2, Q and B have the meanings given in claim 1. Said compounds have a phosphodiesterase-IV inhibiting action and can be used in the treatment of allergic disorders, asthma, chronic bronchitis, atopic dermatitis, psoriasis and other skin diseases, inflammatory diseases, auto-immune diseases such as rheumatoid arthritis, multiple sclerosis, Crohn's disease, diabetes mellitus or ulcerative colitis, osteoporosis, transplant rejection reactions, cachexia, tumour growth or tumour metastases, sepsis, memory disturbances, atherosclerosis and AIDS.
公开/授权文献
- EP1087946A1 ARYLALKANOYLPYRIDAZINE 公开/授权日:2001-04-04
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