发明授权
EP1089994B9 NOUVELLE FORME DE L'IRBESARTAN, PROCEDES POUR OBTENIR LADITE FORME ET COMPOSITIONS PHARMACEUTIQUES EN CONTENANT
无效
厄贝沙坦的新形式，METHODS这种形式获得并含有YOU的药物组合物
- 专利标题： NOUVELLE FORME DE L'IRBESARTAN, PROCEDES POUR OBTENIR LADITE FORME ET COMPOSITIONS PHARMACEUTIQUES EN CONTENANT
- 专利标题（英）： Novel form of irbesartan, methods for obtaining said form and pharmaceutical compositions containing same
- 专利标题（中）： 厄贝沙坦的新形式，METHODS这种形式获得并含有YOU的药物组合物
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申请号： EP99923712.6申请日： 1999-06-10
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公开(公告)号： EP1089994B9公开(公告)日： 2008-08-27
- 发明人: FRANC, Bruno , HOFF, Christian , KIANG, San , LINDRUD, Mark, D. , MONNIER, Olivier , WEI, Chenkou
- 申请人： Sanofi-Aventis
- 申请人地址： 174, Avenue de France 75013 Paris FR
- 专利权人： Sanofi-Aventis
- 当前专利权人： Sanofi-Aventis
- 当前专利权人地址： 174, Avenue de France 75013 Paris FR
- 代理机构： Thouret-Lemaitre, Elisabeth
- 优先权： FR9808037 19980624
- 国际公布： WO1999067236 19991229
- 主分类号： C07D403/10
- IPC分类号： C07D403/10 ; A61K31/415
摘要：
The invention concerns irbesartan form A having a modified crystalline habit such that length/width ratio ranges between 1:1 and 10:1, preferably between 1:1 and 5:1 and a method for preparing said crystalline habit. The method is characterised in that it consists in either subjecting a crystalline suspension of irbesartan form A having acicular habit to at least a temperature oscillating step, or in subjecting a crystalline suspension of irbesartan form A having acicular habit to a mechanical shearing. The invention also concerns a pharmaceutical composition containing said irbesartan crystalline habit.
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