发明授权
EP1091763B1 ANTIVIRALE UND ANTIRETROVIRALE RADIOIMMUNPHARMAKA AUF DER BASIS VON ALPHA- UND BETA-STRAHLERN
有权
抗病毒和抗逆转录病毒RADIO免疫PHARMAKA基于Alpha和Beta反射
- 专利标题： ANTIVIRALE UND ANTIRETROVIRALE RADIOIMMUNPHARMAKA AUF DER BASIS VON ALPHA- UND BETA-STRAHLERN
- 专利标题（英）： Antiviral and antiretroviral radioimmunomedicaments based on alpha-emitters and beta-emitters
- 专利标题（中）： 抗病毒和抗逆转录病毒RADIO免疫PHARMAKA基于Alpha和Beta反射
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申请号： EP99941408.9申请日： 1999-06-29
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公开(公告)号： EP1091763B1公开(公告)日： 2003-09-17
- 发明人: Bergter, Wolfgang
- 申请人： Bergter, Wolfgang
- 申请人地址： Apt. 17, Posthof 2 37081 Göttingen DE
- 专利权人： Bergter, Wolfgang
- 当前专利权人： Bergter, Wolfgang
- 当前专利权人地址： Apt. 17, Posthof 2 37081 Göttingen DE
- 代理机构： Heitsch, Wolfgang
- 优先权： DE19828732 19980629
- 国际公布： WO00000223 20000106
- 主分类号： A61K51/10
- IPC分类号： A61K51/10 ; A61P31/12
摘要：
The invention relates to a pharmaceutical preparation comprising a radioimmunological conjugate (RIK) for in-vivo elimination of virus-replicating cells in HIV-1, HIV-2, HIV-3, HTLV-1, HTLV-2, HBV, HCV, HDV, CMV, EBV, HHV8 infections and in other chronic virus infections. The radioimmunological conjugate is characterized in that it contains, as immunologically effective constituents; d) a monoclonal antibody or the antigen-binding fragment thereof against a viral or virus-induced antigen expressed on the plasma membrane of virus-infected cells, or; e) a receptor molecule or the fragment thereof with an affinity to an epitope of the viral structural proteins expressed on the plasma membrane of infected cells; or f) a fragment of the cellular receptor molecule, said fragment being modified by mutagenesis, with an affinity to an epitope of the viral structural proteins expressed on the plasma membrane of infected cells. Said conjugate is also characterized in that it contains d) an alpha emitter or a beta emitter as a radioactive constituent. The inventive pharmaceutical preparation also optionally comprises a pharmaceutical carrier and/or adjuvant.
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