发明公开
EP1095015A2 SULFONYLAMINO-CARBONSÄURE-N-ARYLAMIDE ALS GUANYLATCYCLASE-AKTIVATOREN 有权
磺酰炭酸-N-芳基酰胺ALS鸟苷酸环化酶活化剂

  • 专利标题: SULFONYLAMINO-CARBONSÄURE-N-ARYLAMIDE ALS GUANYLATCYCLASE-AKTIVATOREN
  • 专利标题(英): Sulfonylamino carboxylic acid n-arylamides as guanylate cyclase activators
  • 专利标题(中): 磺酰炭酸-N-芳基酰胺ALS鸟苷酸环化酶活化剂
  • 申请号: EP99936460.7
    申请日: 1999-06-25
  • 公开(公告)号: EP1095015A2
    公开(公告)日: 2001-05-02
  • 发明人: SCHINDLER, UrsulaSCHÖNAFINGER, KarlSTROBEL, Hartmut
  • 申请人: Aventis Pharma Deutschland GmbH
  • 申请人地址: Brüningstrasse 50 65929 Frankfurt am Main DE
  • 专利权人: Aventis Pharma Deutschland GmbH
  • 当前专利权人: Aventis Pharma Deutschland GmbH
  • 当前专利权人地址: Brüningstrasse 50 65929 Frankfurt am Main DE
  • 优先权: DE19830431 19980708
  • 国际公布: WO0002850 20000120
  • 主分类号: C07C311/21
  • IPC分类号: C07C311/21
SULFONYLAMINO-CARBONSÄURE-N-ARYLAMIDE ALS GUANYLATCYCLASE-AKTIVATOREN
摘要:
The invention relates to compounds of formula (I), wherein A?1, A2, R2 and R3¿ have the meanings cited in the claims. Said compounds are valuable pharmaceutical active substances for the treatment and prophylaxis of diseases, e.g. cardiovascular diseases such a hypertension, angina pectoris, heart failures, thrombosis or atherosclerosis. The compounds of formula (I) have the ability of modulating endogenous production of cyclic guanosine monophosphate (cGMP) and are generally suitable for treatment and prophylaxis of pathological states associated with cGMP metabolic disorders. The invention also relates to the use of compounds of formula (I) for treatment and prophylaxis of the above-mentioned pathological states and for producing corresponding medicaments, to pharmaceutical preparations containing said compounds and to a method of production.
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