发明公开
- 专利标题: FAP ALPHA-SPECIFIC ANTIBODY WITH IMPROVED PRODUCIBILITY
- 专利标题(中): 具有改进的可制造性抗体
-
申请号: EP99923439.6申请日: 1999-04-22
-
公开(公告)号: EP1098979A2公开(公告)日: 2001-05-16
- 发明人: PARK, John, Edward , GARIN-CHESA, Pilar , BAMBERGER, Uwe , RETTIG, Wolfgang, J. , LEGER, Olivier , SALDANHA, Jose
- 申请人: Boehringer Ingelheim International GmbH
- 申请人地址: 55216 Ingelheim DE
- 专利权人: Boehringer Ingelheim International GmbH
- 当前专利权人: Boehringer Ingelheim International GmbH
- 当前专利权人地址: 55216 Ingelheim DE
- 代理机构: Laudien, Dieter, Dr.
- 优先权: EP98107925 19980430
- 国际公布: WO9957151 19991111
- 主分类号: C12N15/13
- IPC分类号: C12N15/13 ; C07K16/40 ; C07K16/46 ; C12N15/62 ; C12N15/85 ; C12N5/10 ; C07K19/00 ; A61K47/48 ; A61K51/10 ; A61K39/395 ; G01N33/577 ; G01N33/574
摘要:
Recombinant antibody proteins are provided that specifically bind fibroblast activation protein alpha (FAPα) and comprise framework modifications resulting in the improved producibility in host cells. The invention also relates to the use of said antibodies for diagnostic and therapeutic purposes and methods of producing said antibodies.
公开/授权文献
- EP1098979B1 ANTIBODY WITH IMPROVED PRODUCIBILITY 公开/授权日:2007-03-14
信息查询
IPC分类: