In order to control weeds in cotton cultures consisting of tolerant or resistant mutants or transgenic cotton plants, herbicide combinations (A) + (B), optionally in the presence of safeners, are particularly suitable, said combinations having an active content of: (A) herbicides exhibiting broad-spectrum effectiveness from group (A1) glufosinate(salts) and allied compounds; (A2) glyphosate(salts) and allied compounds such as sulfosate and (A3) imidazolinones such as imazethapyr, imazapyr, imazaquin, imazamox or the salts thereof, (A4) herbicidal azoles from the group protoporphyrinogen oxidase inhibitors (PPO inhibitors) and (A5) hydroxybenzonitrile; and (B) herbicides from the group consisting of (B0) one or more herbicides structurally different from the above-mentioned group (A), (B1) herbicides exhibiting activity against monocotyledonous and dicotyledonous weeds with an effect on both the foliage and the soil, (B2) herbicides exhibiting activity against dicotyledonous weeds having an effect primarily on the foliage, (B3) herbicides exhibiting activity against monocotyledonous weeds having an effect primarily on the foliage and (B4) herbicides exhibiting activity primarily against monocotyledonous weeds having an effect on both the foliage and the soil.