发明公开
EP1104456A1 ENGINEERED ANTIGEN-PRESENTING CELLS EXPRESSING AN ARRAY OF ANTIGENS AND USES THEREOF
审中-公开
基因工程抗原提呈细胞抗原集团PRESENT及其用途
- 专利标题： ENGINEERED ANTIGEN-PRESENTING CELLS EXPRESSING AN ARRAY OF ANTIGENS AND USES THEREOF
- 专利标题（中）： 基因工程抗原提呈细胞抗原集团PRESENT及其用途
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申请号： EP99941010.3申请日： 1999-08-10
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公开(公告)号： EP1104456A1公开(公告)日： 2001-06-06
- 发明人: WILLIAMS, Lewis, T. , GIEDLIN, Martin , ESCOBEDO, Jaime , COLLINS, Amy, L. , FONG, Timothy
- 申请人： CHIRON CORPORATION
- 申请人地址： 4560 Horton Street Emeryville,California 94608 US
- 专利权人： CHIRON CORPORATION
- 当前专利权人： CHIRON CORPORATION
- 当前专利权人地址： 4560 Horton Street Emeryville,California 94608 US
- 代理机构： Irvine, Jonquil Claire
- 优先权： US96131P 19980810
- 国际公布： WO0009665 20000224
- 主分类号： C12N5/06
- IPC分类号： C12N5/06 ; C12N15/79
摘要：
The present invention provides a method for presentation of multiple disease associated antigens in antigen-presenting cells which can be used to generate a prophylactic or therapeutic immune response against the disease with which the antigens are associated. The method employs differential screening of nucleic acid sequences expressed by target and non-target cells. By identifying nucleic acid sequences preferentially expressed in a target cell population and expressing the identified sequences in antigen-presenting cells, one can stimulate an immune response directed at a target cell population without being limited to single, previously identified antigens.
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