发明公开
EP1120412A4 PROCESSES FOR THE PREPARATION OF 4-SUBSTITUTED BENZOPYRAN DERIVATIVES
审中-公开
用于生产4苯并吡喃SUBSITUIERTEN
- 专利标题: PROCESSES FOR THE PREPARATION OF 4-SUBSTITUTED BENZOPYRAN DERIVATIVES
- 专利标题(中): 用于生产4苯并吡喃SUBSITUIERTEN
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申请号: EP99969719申请日: 1999-09-30
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公开(公告)号: EP1120412A4公开(公告)日: 2002-09-11
- 发明人: SUZUKI YUKIO , ISHIZAWA TAKENORI , KHLEBNIKOV VLADIMIR A , WATANABE MASASHI
- 申请人: CHUGAI PHARMACEUTICAL CO LTD
- 专利权人: CHUGAI PHARMACEUTICAL CO LTD
- 当前专利权人: CHUGAI PHARMACEUTICAL CO LTD
- 优先权: JP27756198 1998-09-30; JP27795298 1998-09-30; JP27874198 1998-09-30
- 主分类号: C07D311/58
- IPC分类号: C07D311/58 ; A61K31/35
摘要:
A process for the preparation of 4-substituted benzopyran derivatives which comprises preparing N-(2-cyanoethyl)-5-fluoro-4-fluoromethyl-4-(4-trifluoromethylphenoxy)-2-pentynamide from 1-fluoro-2-fluoromethyl-3-butyn-2-yl 4-trifluoromethylphenyl ether and cyclizing this pentynamide derivative into 2,2-bis(fluoromethyl)-N-(2-cyanoethyl)-6-trifluoromethyl-2H-1-benzopyran-4-carboxamide; and other processes therefor. The processes make it possible to prepare the benzopyran derivatives in a shortened process time as compared with those of the prior art with high safety through easy purification.
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