发明公开
EP1120412A4 PROCESSES FOR THE PREPARATION OF 4-SUBSTITUTED BENZOPYRAN DERIVATIVES 审中-公开
用于生产4苯并吡喃SUBSITUIERTEN

PROCESSES FOR THE PREPARATION OF 4-SUBSTITUTED BENZOPYRAN DERIVATIVES
摘要:
A process for the preparation of 4-substituted benzopyran derivatives which comprises preparing N-(2-cyanoethyl)-5-fluoro-4-fluoromethyl-4-(4-trifluoromethylphenoxy)-2-pentynamide from 1-fluoro-2-fluoromethyl-3-butyn-2-yl 4-trifluoromethylphenyl ether and cyclizing this pentynamide derivative into 2,2-bis(fluoromethyl)-N-(2-cyanoethyl)-6-trifluoromethyl-2H-1-benzopyran-4-carboxamide; and other processes therefor. The processes make it possible to prepare the benzopyran derivatives in a shortened process time as compared with those of the prior art with high safety through easy purification.
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