发明公开
EP1131307A1 VERFAHREN ZUR HERSTELLUNG VON 2-ALKYL- 3-(4,5- DIHYDROISOXAZOL- 3-YL)-HALOGENBENZOLEN
有权
用于生产2-烷基-3-（4,5-二氢异恶唑-3-基）-HALOGENBENZOLEN
- 专利标题： VERFAHREN ZUR HERSTELLUNG VON 2-ALKYL- 3-(4,5- DIHYDROISOXAZOL- 3-YL)-HALOGENBENZOLEN
- 专利标题（英）： Method of producing 2-alkyl-3-(4,5-dihydroisoxazole-3-yl)-halobenzenes
- 专利标题（中）： 用于生产2-烷基-3-（4,5-二氢异恶唑-3-基）-HALOGENBENZOLEN
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申请号： EP99960983.7申请日： 1999-11-17
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公开(公告)号： EP1131307A1公开(公告)日： 2001-09-12
- 发明人: RACK, Michael , GÖTZ, Norbert , HAGEN, Helmut , VON DEYN, Wolfgang , BAUMANN, Ernst , LOCHTMAN, Rene , GEBHARDT, Joachim
- 申请人： BASF AKTIENGESELLSCHAFT
- 申请人地址： 67056 Ludwigshafen DE
- 专利权人： BASF AKTIENGESELLSCHAFT
- 当前专利权人： BASF AKTIENGESELLSCHAFT
- 当前专利权人地址： 67056 Ludwigshafen DE
- 优先权： DE19853039 19981118
- 国际公布： WO0029395 20000525
- 主分类号： C07D261/04
- IPC分类号： C07D261/04
摘要：
The invention relates to a novel method of producing the compounds of formula (I) wherein the substituents have the following meanings: n is 0,1 or 2; R1, R2 represent C¿1?-C6-alkyl; R?3, R4, R5¿ are hydrogen, C¿1?-C6-alkyl or R?4 and R5¿ together form a bond; R6 is C1, Br. Said method comprises the following steps: a synthesis sequence starting from 1,2-dialkylbenzenes of formula (II); halogenation to form 3,6-dihalogen-1,2-dialkylbenzenes; haloalkylation to form benzyl bromides; oxidation to form benzaldehydes; reaction with alkenes to form isoxazoles; reaction to form thioethers and optionally oxidation to form sulfenyl or sulfonyl derivatives of formula (I).
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