发明公开
- 专利标题： NOUVEAUX DERIVES D'ACYLGUANIDINES, LEUR PROCEDE DE PREPARATION, LEUR APPLICATION COMME MEDICAMENTS ET LES COMPOSITIONS PHARMACEUTIQUES LES RENFERMANT
- 专利标题（英）： Novel acylguanidine derivatives, method for preparing same, application as medicines and pharmaceutical compositions containing them
- 专利标题（中）： 酰基胍的衍生物，方法及其它们的使用如医药和含有药物组合物
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申请号： EP99956120.2申请日： 1999-11-23
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公开(公告)号： EP1133478A1公开(公告)日： 2001-09-19
- 发明人: CARNIATO, Denis , GADEK, Thomas, R. , GOURVEST, Jean-François , KNOLLE, Jochen , PEYMAN, Anurschirwan , RUXER, Jean-Marie , BODARY, Sarah, C.
- 申请人： Aventis Pharma S.A. , Genentech, Inc.
- 申请人地址： 20, avenue Raymond Aron 92160 Antony FR
- 专利权人： Aventis Pharma S.A.,Genentech, Inc.
- 当前专利权人： Aventis Pharma S.A.,Genentech, Inc.
- 当前专利权人地址： 20, avenue Raymond Aron 92160 Antony FR
- 代理机构： Rousseau, Pierrick Edouard
- 优先权： FR9814781 19981124
- 国际公布： WO0031046 20000602
- 主分类号： C07D239/16
- IPC分类号： C07D239/16 ; C07C279/22 ; C07C311/06 ; A61K31/505
摘要：
The invention concerns compounds of formula (I) wherein: m = 1, 2 or 3; n = 1, 2 or 3; R5 represents a group selected among COR6, CO2R6, SO2R6, SO2NHR6, SO2NHCOR6, SO2NHCO2R6, CONH2 and CONHR6; R1, R2, R4, R6, R7 and R8 are as defined in the description, in all their possible isomeric forms, their physiologically acceptable salts, their prodrugs. The invention also concerns the method for preparing them, their use as medicines in particular for treating osteoporosis and the pharmaceutical compositions containing them.
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