发明授权
- 专利标题： FARNESYL PROTEIN TRANSFERASE INHIBITORS
- 专利标题（中）： 法呢蛋白抑制剂转移酶
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申请号： EP99967139.9申请日： 1999-12-16
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公开(公告)号： EP1140904B1公开(公告)日： 2005-04-20
- 发明人: GUZI, Timothy , RANE, Dinanath, F. , MALLAMS, Alan, K. , COOPER, Alan, B. , DOLL, Ronald, J. , GIRIJAVALLABHAN, Viyyoor, M. , TAVERAS, Arthur, G. , STRICKLAND, Corey , KELLY, Joseph, M. , CHAO, Jianping
- 申请人： SCHERING CORPORATION
- 申请人地址： 2000 Galloping Hill Road Kenilworth, New Jersey 07033-0530 US
- 专利权人： SCHERING CORPORATION
- 当前专利权人： SCHERING CORPORATION
- 当前专利权人地址： 2000 Galloping Hill Road Kenilworth, New Jersey 07033-0530 US
- 代理机构： Ritter, Stephen David
- 优先权： US216560 19981218
- 国际公布： WO2000037458 20000629
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; A61K31/497 ; A61K31/44 ; A61P43/00
摘要：
Disclosed are compounds of formula (1.0), wherein R8 represents a cyclic moiety to which is bound an imodazolylalkyl group; R9 represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.
公开/授权文献
- EP1140904A1 FARNESYL PROTEIN TRANSFERASE INHIBITORS 公开/授权日：2001-10-10
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