发明授权
- 专利标题： NOVEL INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
- 专利标题（中）： 法呢蛋白抑制剂转移酶
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申请号： EP99965906.3申请日： 1999-12-22
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公开(公告)号： EP1140909B1公开(公告)日： 2005-07-06
- 发明人: COOPER, Alan, B. , DOLL, Ronald, J. , FERREIRA, Johan, A. , GANGULY, Ashit , GIRIJAVALLABHAN, Viyyoor, M. , TAVERAS, Arthur, G. , CHAO, Jianping , BALDWIN, John, J. , HUANG, Chia-Yu , LI, Ge
- 申请人： Schering Corporation , Pharmacopeia Drug Discovery, Inc.
- 申请人地址： 2000 Galloping Hill Road Kenilworth, NJ 07033-0530 US
- 专利权人： Schering Corporation,Pharmacopeia Drug Discovery, Inc.
- 当前专利权人： Schering Corporation,Pharmacopeia Drug Discovery, Inc.
- 当前专利权人地址： 2000 Galloping Hill Road Kenilworth, NJ 07033-0530 US
- 代理机构： Gross, Ulrich-Maria
- 优先权： US220314 19981223
- 国际公布： WO2000039119 20000706
- 主分类号： C07D403/12
- IPC分类号： C07D403/12 ; C07D401/14 ; C07D241/04 ; A61K31/496 ; A61P35/00
摘要：
Novel compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl-protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel aminooxyamide compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.
公开/授权文献
- EP1140909A1 NOVEL INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE 公开/授权日：2001-10-10
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