发明公开
- 专利标题： HUMAN GLYCOSYLPHOSPHATIDYLINOSITOL SPECIFIC PHOSPHOLIPASE D VARIANTS AND USES THEREOF
- 专利标题（中）： 人类糖基特异性磷脂酶D和使用的变型
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申请号： EP99963641.8申请日： 1999-12-23
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公开(公告)号： EP1141334A2公开(公告)日： 2001-10-10
- 发明人: SCHOFIELD, Julian , RADEMACHER, Thomas William
- 申请人： UNIVERSITY COLLEGE LONDON
- 申请人地址： 5 Gower Street London WC1E 6BT GB
- 专利权人： UNIVERSITY COLLEGE LONDON
- 当前专利权人： UNIVERSITY COLLEGE LONDON
- 当前专利权人地址： 5 Gower Street London WC1E 6BT GB
- 代理机构： Kiddle, Simon John
- 优先权： GB9828712 19981224; GB9828715 19981224; GB9828713 19981224
- 国际公布： WO0039285 20000706
- 主分类号： C12N15/55
- IPC分类号： C12N15/55
摘要：
Glycosyl phosphatidy linositol specific phospholipase D (GPI-PLD) proteins and their medical uses are disclosed, in particular in the treatment and diagnosis of diabetes and complications of diabetes such as insulin resistance, liver dysfunction, disorders involving pancreatectomies and conditions mediated by a product of an infectious organism which is capable of inhibiting GPI-PLD, such as septic shock. The present invention further relates to variant GPI-PLD polypeptides modified at the phosphorylation site at amino acids 689-692 of the mature human wild-type protein.
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