发明公开
EP1142900A1 SIASTATIN B DERIVATIVES HAVING GLYCOSIDASE INHIBITORY ACTIVITIES AND PROCESS FOR PRODUCING THE SAME
有权
精氨酸衍生物麻醉剂甘氨酸酶INHINBOR-AKTIVITÄTUND EIN VERFAHREN ZUR HERSTELLUNG DERSELBEN
- 专利标题： SIASTATIN B DERIVATIVES HAVING GLYCOSIDASE INHIBITORY ACTIVITIES AND PROCESS FOR PRODUCING THE SAME
- 专利标题（中）： 精氨酸衍生物麻醉剂甘氨酸酶INHINBOR-AKTIVITÄTUND EIN VERFAHREN ZUR HERSTELLUNG DERSELBEN
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申请号： EP99961360.7申请日： 1999-12-24
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公开(公告)号： EP1142900A1公开(公告)日： 2001-10-10
- 发明人: NISHIMURA, Yoshio , SHITARA, Eiki , TAKEUCHI, Tomio
- 申请人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI , Meiji Seika Kaisha, Ltd.
- 申请人地址： 14-23, Kami Ohsaki 3-chome Shinagawa-ku, Tokyo 141-0021 JP
- 专利权人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI,Meiji Seika Kaisha, Ltd.
- 当前专利权人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI,Meiji Seika Kaisha, Ltd.
- 当前专利权人地址： 14-23, Kami Ohsaki 3-chome Shinagawa-ku, Tokyo 141-0021 JP
- 代理机构： Stalla-Bourdillon, Bernard
- 优先权： JP37027798 19981225
- 国际公布： WO0039140 20000706
- 主分类号： C07H7/02
- IPC分类号： C07H7/02 ; A61K31/7008 ; A61P3/04 ; A61P3/10 ; A61P31/12 ; A61P35/00 ; A61P43/00
摘要：
A compound of the formula (I):
and a compound of the formula (V):
as well as a compound of the formula (X):
which are each a novel siastatin B derivative having a potent inhibitory activity against a glycosidase, are now synthesized by new processes.
The compound of the formula (I), the compound of the formula (V) and the compound of the formula (X) have a potent enzyme-inhibitory activity to a glycosidase, which is particularly N -acetyl-galactosaminidase, galactosidase, glucosidase and mannosidase.
and a compound of the formula (V):
as well as a compound of the formula (X):
which are each a novel siastatin B derivative having a potent inhibitory activity against a glycosidase, are now synthesized by new processes.
The compound of the formula (I), the compound of the formula (V) and the compound of the formula (X) have a potent enzyme-inhibitory activity to a glycosidase, which is particularly N -acetyl-galactosaminidase, galactosidase, glucosidase and mannosidase.
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