发明公开
EP1143006A2 Vectors/DNA-sequences from human combinatorial antibody libraries
失效
Vektoren / DNA-Sequenzen aus humanen kombinatorischenAntikörper-Bibliotheken
- 专利标题： Vectors/DNA-sequences from human combinatorial antibody libraries
- 专利标题（中）： Vektoren / DNA-Sequenzen aus humanen kombinatorischenAntikörper-Bibliotheken
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申请号： EP01110609.3申请日： 1996-08-19
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公开(公告)号： EP1143006A2公开(公告)日： 2001-10-10
- 发明人: Knappik, Achim , Pack, Peter , Ge, Liming
- 申请人： MorphoSys AG
- 申请人地址： Am Klopferspitz 19 82152 Martinsried DE
- 专利权人： MorphoSys AG
- 当前专利权人： MorphoSys AG
- 当前专利权人地址： Am Klopferspitz 19 82152 Martinsried DE
- 代理机构： VOSSIUS & PARTNER
- 主分类号： C12N15/63
- IPC分类号： C12N15/63 ; C07K1/04 ; C12N15/13
摘要：
The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.
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