发明公开
EP1143971A1 1-(PIPERIDIN-4-YL)-3-(ARYL)-ISOTHIOUREES SUBSTITUEES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
有权
取代的1-(哌啶-4-基)-3-(芳基)-ISOTHIOHARNSTOFFE,其制备和治疗用途
- 专利标题: 1-(PIPERIDIN-4-YL)-3-(ARYL)-ISOTHIOUREES SUBSTITUEES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
- 专利标题(英): Substituted 1-(piperidin-4-yl)-3-(aryl)-isothioureas, their preparation and therapeutic use
- 专利标题(中): 取代的1-(哌啶-4-基)-3-(芳基)-ISOTHIOHARNSTOFFE,其制备和治疗用途
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申请号: EP00900638.8申请日: 2000-01-21
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公开(公告)号: EP1143971A1公开(公告)日: 2001-10-17
- 发明人: PATOISEAU, Jean-François , RIEU, Jean-Pierre , JOHN, Gareth , LEGRAND, Bruno , VERSCHEURE, Yvan
- 申请人: PIERRE FABRE MEDICAMENT
- 申请人地址: 45, Place Abel Gance 92100 Boulogne-Billancourt FR
- 专利权人: PIERRE FABRE MEDICAMENT
- 当前专利权人: PIERRE FABRE MEDICAMENT
- 当前专利权人地址: 45, Place Abel Gance 92100 Boulogne-Billancourt FR
- 代理机构: Ahner, Francis
- 优先权: FR9900705 19990122
- 国际公布: WO0043011 20000727
- 主分类号: A61K31/445
- IPC分类号: A61K31/445 ; C07D211/58
摘要:
The invention concerns compounds of formula (I) wherein: R1 and R2, identical or different, represent a saturated or unsaturated alkyl radical, branched or not and containing 1 to 7 carbon atoms; R3 to R8, identical or different, represent a hydrogen, an alkyl branched or not and containing 1 to 5 carbon atoms, an acyloxy, branched or not and containing 1 to 5 carbon atoms, a halogeno, nitro, hydroxy, acyl or alkoxy group containing 1 to 5 carbon atoms, a dialkylamino group containing 1 to 5 carbon atoms, a trifluoromethyl or trifluoro methoxyl group; Z represents an oxygen or sulphur atom or methylene; m represents an integer between 0 and 4 inclusively; n represents an integer between 2 and 7 inclusively; and their pure enantiomers and mixtures, the therapeutically acceptable mineral or organic salts of the compounds of formula (I) and their possible hydrates.
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