发明授权
EP1162992B1 CYANOVIRIN CONJUGATES, MATRIX-ANCHORED CYANOVIRIN AND ANTI-CYANOVIRIN ANTIBODY, AND RELATED COMPOSITIONS AND METHODS OF USE
有权
蓝藻抗病毒蛋白偶联物,MATRIX锚蓝藻抗病毒和抗蓝藻抗病毒抗体和相关组合物及其应用
- 专利标题: CYANOVIRIN CONJUGATES, MATRIX-ANCHORED CYANOVIRIN AND ANTI-CYANOVIRIN ANTIBODY, AND RELATED COMPOSITIONS AND METHODS OF USE
- 专利标题(中): 蓝藻抗病毒蛋白偶联物,MATRIX锚蓝藻抗病毒和抗蓝藻抗病毒抗体和相关组合物及其应用
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申请号: EP00913869.4申请日: 2000-03-10
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公开(公告)号: EP1162992B1公开(公告)日: 2005-05-25
- 发明人: BOYD, Michael, R.
- 申请人: The United States of America, as represented by the Secretary Department of Health and Human Services
- 申请人地址: Office of Technology Transfer, National Institutes of Health, 6011 Executive Boulevard Rockville, MD 20852 US
- 专利权人: The United States of America, as represented by the Secretary Department of Health and Human Services
- 当前专利权人: The United States of America, as represented by the Secretary Department of Health and Human Services
- 当前专利权人地址: Office of Technology Transfer, National Institutes of Health, 6011 Executive Boulevard Rockville, MD 20852 US
- 代理机构: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät
- 优先权: US267447 19990312; US416434 19991012
- 国际公布: WO2000053213 20000914
- 主分类号: A61K38/16
- IPC分类号: A61K38/16 ; A61L2/00 ; A61F6/00 ; A61M31/00 ; A61K47/48 ; A61P31/18
摘要:
The present invention provides, among other things, methods of removing virus from a sample, compositions treated in accordance with such methods, a composition comprising a naturally-occurring non- infectious HIV comprising gp120, a composition comprising a solid support matrix to which is attached a cyanovirin or a conjugate thereof, a conjugate comprising a cyanovirin coupled to an anti-cyanovirin antibody or at least one effector component, a composition comprising such a conjugate, methods of inhibiting prophylactically or therapeutically a viral infection of a host, methods of inducing an immune response to a virus in an animal, and a matrix-anchored anti-cyanovirin antibody.
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