发明公开
EP1163522A1 DETECTION D'UNE ACTIVITE SUPERANTIGENIQUE DANS UN ECHANTILLON BIOLOGIQUE 有权
一个MSRV1超抗原诱导活性在生物样品检测

  • 专利标题: DETECTION D'UNE ACTIVITE SUPERANTIGENIQUE DANS UN ECHANTILLON BIOLOGIQUE
  • 专利标题(英): Method for detecting superantigen activity in a biological sample
  • 专利标题(中): 一个MSRV1超抗原诱导活性在生物样品检测
  • 申请号: EP00912720.0
    申请日: 2000-03-20
  • 公开(公告)号: EP1163522A1
    公开(公告)日: 2001-12-19
  • 发明人: PERRON, HervéLAFONT, Monique
  • 申请人: BIO MERIEUX
  • 申请人地址: Chemin de l'Orme 69280 Marcy l'Etoile FR
  • 专利权人: BIO MERIEUX
  • 当前专利权人: BIO MERIEUX
  • 当前专利权人地址: Chemin de l'Orme 69280 Marcy l'Etoile FR
  • 代理机构: Guerre, Dominique
  • 优先权: FR9903622 19990319; FR9913755 19991028
  • 国际公布: WO0057185 20000928
  • 主分类号: G01N33/569
  • IPC分类号: G01N33/569 G01N33/68 G01N33/50 G01N33/564 G01N33/566 G01N33/574 A61K39/00
DETECTION D'UNE ACTIVITE SUPERANTIGENIQUE DANS UN ECHANTILLON BIOLOGIQUE
摘要:
The invention concerns in particular a method for detecting superantigen activity in a biological sample, which consists in: demonstrating a majority spread rate of lymphocytes bearing a Vβ 16 and/or Vβ17 determinant or a majority loss rate of lymphocytes bearing a Vβ16 determinant and a method for detecting a pathological condition in a biological sample which consists in demonstrating at least one of the following parameters: a superantigen activity; a stimulation of the production of cytokines such as IL-6 and INF-η; induced cell apoptosis.
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