发明授权
EP1165115B1 MODULATION OF VASCULAR PERMEABILITY BY MEAN OF TIE2 RECEPTOR ACTIVATORS
有权
调节装置GEFÄSSEPERMEABILITÄTTie2受体激活剂
- 专利标题： MODULATION OF VASCULAR PERMEABILITY BY MEAN OF TIE2 RECEPTOR ACTIVATORS
- 专利标题（中）： 调节装置GEFÄSSEPERMEABILITÄTTie2受体激活剂
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申请号： EP00916545.7申请日： 2000-03-20
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公开(公告)号： EP1165115B1公开(公告)日： 2003-05-28
- 发明人: SURI, Chitra , YANCOPOULOS, George, D. , THURSTON, Gavin , MCDONALD, Donald
- 申请人： REGENERON PHARMACEUTICALS, INC. , The Regents of the University of California
- 申请人地址： 777 Old Saw Mill River Road Tarrytown, NY 10591-6707 US
- 专利权人： REGENERON PHARMACEUTICALS, INC.,The Regents of the University of California
- 当前专利权人： REGENERON PHARMACEUTICALS, INC.,The Regents of the University of California
- 当前专利权人地址： 777 Old Saw Mill River Road Tarrytown, NY 10591-6707 US
- 代理机构： Duckworth, Timothy John
- 优先权： US126539P 19990326; US286033 19990405
- 国际公布： WO00057901 20001005
- 主分类号： A61K38/17
- IPC分类号： A61K38/17 ; A61K38/18 ; A61K39/395 ; A61P9/00
摘要：
The present invention provides for a method of decreasing or inhibiting vascular permeability and/or plasma leakage in a mammal comprising administering to the mammal a TIE2 receptor activator. The invention also provides for a method of decreasing or inhibiting vascular permeability and/or plasma leakage in a mammal comprising administering to the mammal an Ang-2 inactivator such as an anti-Ang-2 neutralizing antibody.
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