A non-needle access device (10) includes a housing (12) having a fluid pathway and an inner chamber (34). A biased plunger (16) is disposed within the inner chamber (34), movable between a first position, and a second position. A main seal (32) seals the inner chamber (34) from the fluid pathway. A vent (20) between the inner chamber (34), the outside of the housing (12) allows air to pass out of and into the inner chamber (34) when the plunger (16) is moved between the first and the second positions.