发明公开
EP1165581A1 PROCEDE DE PREPARATION DU 4'-DEMETHYL -4'- PHOSPHATE-2",3" - BIS PENTAFLUOROPHENOXYACETYL -4",6" -ETHYLIDENE - BETA-D-GLUCOSIDE D'EPIPODOPHYLLOTOXINE, ET DE SES SELS
有权
用于生产鬼臼乙叉甙-4'-脱甲基-4'-磷酸-2 “3" - 双PENTAFLUORPHENOXYACETYL-4”，6" -ETHYLIDEN- BETA-D-葡糖苷及其盐的
- 专利标题： PROCEDE DE PREPARATION DU 4'-DEMETHYL -4'- PHOSPHATE-2",3" - BIS PENTAFLUOROPHENOXYACETYL -4",6" -ETHYLIDENE - BETA-D-GLUCOSIDE D'EPIPODOPHYLLOTOXINE, ET DE SES SELS
- 专利标题（英）： Method for the production of 4'-demethyl - 4'-phosphate-2",3" - bis pentafluorophenoxyacetyl - 4",6"-ethylidene - beta-d- glucoside epipodophyllotoxin and the salts thereof
- 专利标题（中）： 用于生产鬼臼乙叉甙-4'-脱甲基-4'-磷酸-2 “3" - 双PENTAFLUORPHENOXYACETYL-4”，6" -ETHYLIDEN- BETA-D-葡糖苷及其盐的
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申请号： EP00915233.1申请日： 2000-03-29
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公开(公告)号： EP1165581A1公开(公告)日： 2002-01-02
- 发明人: GUMINSKI, Yves , IMBERT, Thierry
- 申请人： PIERRE FABRE MEDICAMENT
- 申请人地址： 45, Place Abel Gance 92100 Boulogne FR
- 专利权人： PIERRE FABRE MEDICAMENT
- 当前专利权人： PIERRE FABRE MEDICAMENT
- 当前专利权人地址： 45, Place Abel Gance 92100 Boulogne FR
- 代理机构： Ahner, Francis
- 优先权： FR9903877 19990329
- 国际公布： WO0058324 20001005
- 主分类号： C07H15/207
- IPC分类号： C07H15/207 ; C07H17/04
摘要：
The present invention relates to a method for the production of 4'-demethyl -4'- phosphate-2',3' -bispentafluorophenoxyacetyl - 4',6'-ethylidene - β-D-glucoside epipodophyllotoxin, characterized in that 2,3-bis pentafluorophenoxyacetyl-1-O-triethylsilyl-β-D-glucopyranoside is condensed with 4'-demethyl-4'-aryloxyacetyl-epipodophyllotoxin.
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