发明公开
- 专利标题： PRODRUGS VON THROMBININHIBITOREN
- 专利标题（英）： Prodrugs of thrombin inhibitors
- 专利标题（中）： 凝血酶抑制剂的前药
-
申请号： EP00920661.6申请日： 2000-04-05
-
公开(公告)号： EP1165601A2公开(公告)日： 2002-01-02
- 发明人: BAUCKE, Dorit , MACK, Helmut , SEITZ, Werner , HORNBERGER, Wilfried , BACKFISCH, Gisela , DELZER, Jürgen
- 申请人： BASF AKTIENGESELLSCHAFT
- 申请人地址： 67056 Ludwigshafen DE
- 专利权人： BASF AKTIENGESELLSCHAFT
- 当前专利权人： BASF AKTIENGESELLSCHAFT
- 当前专利权人地址： 67056 Ludwigshafen DE
- 代理机构： Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät
- 优先权： DE19915930 19990409; DE19934123 19990723; DE19947920 19991006
- 国际公布： WO0061609 20001019
- 主分类号： C07K5/02
- IPC分类号： C07K5/02 ; C07K5/065 ; A61K38/05 ; A61P7/02
摘要：
The invention relates to prodrugs of pharmacologically active, five-membered heterocyclic amidines from which in vivo compounds are obtained, these compounds being competitive inhibitors of trypsin-type serin proteases, especially thrombin and kininogenases such as kallikrein. The invention also relates to the production of these prodrugs and to their use as medicaments, to pharmaceutical compositions that contain the prodrugs of the active compounds as components, and to the use of the compounds as thrombin inhibitors, anticoagulants and anti-inflammatory agents.
信息查询
