发明公开
EP1167380A3 11.alpha.-hydroxy-steroid-4,6-dien-3-one compounds and a process for their preparation
失效
11.alpha.羟基类固醇孕甾-4,6-二烯-3-酮化合物和它们的制备方法
- 专利标题: 11.alpha.-hydroxy-steroid-4,6-dien-3-one compounds and a process for their preparation
- 专利标题(中): 11.alpha.羟基类固醇孕甾-4,6-二烯-3-酮化合物和它们的制备方法
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申请号: EP01122428.4申请日: 1996-12-11
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公开(公告)号: EP1167380A3公开(公告)日: 2004-12-08
- 发明人: NG, John S. , Wang, Ping T. , Baez, Julio A. , Liu, Chin , Anderson, Dennis K. , Lawson, Jon P. , Erb, Dernhard , Wieczorek, Joseph , Mucciariello, Gennaro , Vanzanella, Fortunato , Kunda, Sastry A. , Letendre, Leo J. , Pozzo, Mark J. , Sing, Yuen-Lung L. , Yonan, Edward E.
- 申请人: G.D. Searle & Co.
- 申请人地址: P.O. Box 5110 Chicago, IL 60680-9899 US
- 专利权人: G.D. Searle & Co.
- 当前专利权人: G.D. Searle & Co.
- 当前专利权人地址: P.O. Box 5110 Chicago, IL 60680-9899 US
- 代理机构: Strych, Werner Dr.
- 优先权: US8455P 19951211; US763910 19961211
- 主分类号: C07J21/00
- IPC分类号: C07J21/00 ; C07J31/00 ; C07J53/00 ; C07J71/00 ; C12P33/00 ; C12P33/10 ; C12Q1/02
摘要:
Compounds of Formula VIII wherein -A-A- represents the group -CHR4-CHR5- or -CR4=CR5-, R3, R4 and R5 are independently selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl, lower alkoxy, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, cyano, aryloxy, -B-B- represents the group -CHR6-CHR7- or an alpha- or beta- oriented group: where R6 and R7 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano, aryloxy, and R8 and R9 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano, aryloxy, or R8 and R9 together comprise a carbocyclic or heterocyclic ring structure, or R8 and R9 together with R6 or R7 comprise a carbocyclic or heterocyclic ring structure fused to the pentacyclic D ring, their intermediates and processes for preparing them.
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