发明公开
- 专利标题： CYANOPYRROLES AS PROGESTERONE RECEPTOR AGONISTS
- 专利标题（中）： 氰基吡咯孕酮受体激动剂
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申请号： EP00932005.2申请日： 2000-05-01
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公开(公告)号： EP1173433A1公开(公告)日： 2002-01-23
- 发明人: COLLINS, Mark, A. , MACKNER, Valerie, A. , ZHI, Lin , JONES, Todd, K. , TEGLEY, Christopher, M. , WROBEL, Jay, E. , EDWARDS, James, P.
- 申请人： American Home Products Corporation , LIGAND PHARMACEUTICALS INCORPORATED
- 申请人地址： Five Giralda Farms Madison, New Jersey 07840 US
- 专利权人： American Home Products Corporation,LIGAND PHARMACEUTICALS INCORPORATED
- 当前专利权人： American Home Products Corporation,LIGAND PHARMACEUTICALS INCORPORATED
- 当前专利权人地址： Five Giralda Farms Madison, New Jersey 07840 US
- 代理机构： Hale, Stephen Geoffrey
- 优先权： US304550 19990504; US552544 20000419
- 国际公布： WO0066581 20001109
- 主分类号： C07D413/04
- IPC分类号： C07D413/04 ; C07D403/04 ; A61K31/40 ; A61P15/16
摘要：
This invention provides a progesterone receptor antagonist of formula (1) having the structure wherein T is O, S, or absent; R1, and R2 are each, independently, hydrogen, alkyl, substituted alkyl; or R1 and R2 are taken together to form a ring and together contain -CH2(CH2)nCH2-, -CH2CH2CMe2CH2CH2-, -O(CH2)pCH2-, -O(CH2)qO-, -CH2CH2OCH2CH2-, or -CH2CH2NR7CH2CH2-; n=1-5; p=1-4; q=1-4; R3 is hydrogen, OH, NH2, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, or CORA; RA is hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R¿4? is hydrogen, halogen, CN, NH2, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R5 is hydrogen, alkyl, or substituted alkyl; R6 is hydrogen, alkyl, substituted alkyl, or COR?B; RB¿ is hydrogen, alkyl, substituted alkyl, alkoxy, substituted alkoxy, aminoalkyl, or substituted aminoalkyl; R¿7? is hydrogen or alkyl; or a pharmaceutically acceptable salt thereof.
公开/授权文献
- EP1173433B1 CYANOPYRROLES AS PROGESTERONE RECEPTOR AGONISTS 公开/授权日：2005-12-28
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