发明公开
EP1175213A2 HETEROCYCLIC AROMATIC COMPOUNDS USEFUL AS GROWTH HORMONE SECRETAGOGUES
审中-公开
杂环化合物FOR AROMTISCHE诱导GH分泌
- 专利标题： HETEROCYCLIC AROMATIC COMPOUNDS USEFUL AS GROWTH HORMONE SECRETAGOGUES
- 专利标题（中）： 杂环化合物FOR AROMTISCHE诱导GH分泌
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申请号： EP00913733.2申请日： 2000-03-02
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公开(公告)号： EP1175213A2公开(公告)日： 2002-01-30
- 发明人: ROBL, Jeffrey , TINO, Joseph, A. , HERNANDEZ, Andres, S. , LI, James, J. , LI, Jun , SWARTZ, Stephen, G.
- 申请人： BRISTOL-MYERS SQUIBB COMPANY
- 申请人地址： P.O. Box 4000 Princeton, NJ 08543-4000 US
- 专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人地址： P.O. Box 4000 Princeton, NJ 08543-4000 US
- 代理机构： VOSSIUS & PARTNER
- 优先权： US124131P 19990312; US154919P 19990921
- 国际公布： WO0054729 20000921
- 主分类号： A61K31/41
- IPC分类号： A61K31/41 ; A61K31/4178 ; A61K31/4439 ; A61K31/5377 ; A61P3/04 ; A61P5/08 ; A61P5/48 ; A61P19/10 ; C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D403/14 ; C07D413/12 ; C07D413/14
摘要：
Heterocyclic aromatic compounds are provided which are useful in stimulating endogenous production or release of growth hormone and in treating obesity, osteoporosis (improving bone density) and in improving muscle mass and muscle strength. The heterocyclic aromatic compounds have structure (I) including pharmaceutically acceptable salts thereof and all stereoisomers thereof, wherein Xa is heteroaryl, preferably (a), (b) or (c) and R1, R1a, R6, Y, Xb, A, B, Z, R3, R4, R4a, R5 and R5a are as defined herein.
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