发明公开
- 专利标题: PIPERAZINE DERIVATIVES USEFUL AS CCR5 ANTAGONISTS
- 专利标题(中): 哌嗪衍生物有用AS CCR5拮抗剂
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申请号: EP00926486.2申请日: 2000-05-01
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公开(公告)号: EP1175401A1公开(公告)日: 2002-01-30
- 发明人: BAROUDY, Bahige, M. , CLADER, John, W. , JOSIEN, Hubert, B. , MCCOMBIE, Stuart, W. , MCKITTRICK, Brian, A. , MILLER, Michael, W. , NEUSTADT, Bernard, R. , PALANI, Anandan , SMITH, Elizabeth, M. , STEENSMA, Ruo , TAGAT, Jayaram, R. , VICE, Susan, F. , LAUGHLIN, Mark, A. , GILBERT, Eric , LABROLI, Marc, A.
- 申请人: SCHERING CORPORATION
- 申请人地址: 2000 Galloping Hill Road Kenilworth, New Jersey 07033-0530 US
- 专利权人: SCHERING CORPORATION
- 当前专利权人: SCHERING CORPORATION
- 当前专利权人地址: 2000 Galloping Hill Road Kenilworth, New Jersey 07033-0530 US
- 代理机构: Ritter, Stephen David
- 优先权: US305266 19990504
- 国际公布: WO0066558 20001109
- 主分类号: C07D211/58
- IPC分类号: C07D211/58 ; C07D401/06 ; C07D405/12 ; C07D401/10 ; C07D413/06 ; C07D409/06 ; A61K31/496 ; A61P31/12 ; A61P19/00
摘要:
The use of CCR5 antagonists of formula (I) or a pharmaceutically acceptable salt thereof, wherein: R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R1 is hydrogen or alkyl; R2 is substituted phenyl, substituted heteroaryl, naphthyl, fluorenyl, diphenylmethyl or optionally substituted phenyl- or heteroaryl-alkyl; R3 is hydrogen, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, or optionally substituted phenyl, phenylalkyl, naphthyl, naphthylalkyl, heteroaryl or heteroarylalkyl; R?4, R5 and R7¿ are hydrogen or alkyl; R6 is hydrogen, alkyl or alkenyl; for the treatment of HIV, solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis is disclosed, as well as novel compounds, pharmaceutical compositions comprising them, and the combination of CCR5 antagonists of the invention in combination with antiviral agents useful in the treatment of HIV or agents useful in the treatment of inflammatory diseases.
公开/授权文献
- EP1175401B1 PIPERAZINE DERIVATIVES USEFUL AS CCR5 ANTAGONISTS 公开/授权日:2005-07-20
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