Anti-inflammatory agents and inhibitors against increase in ocular tension caused by irradiation with lasers, containing as the active ingredient 1,4-dihydropyridine derivatives represented by general formula (I) or acid addition salts thereof wherein X and X are each independently hydrogen, fluoromethyl, fluoromethoxy, halogeno, cyano, or nitro; R is lower alkyl; R is acyl, alkoxycarbonyl, acylalkyl, N-alkylated carbamoylalkyl, alkoxyalkyl, alkoxycarbonylalkyl, acyloxyalkyl, nitratoalkyl, cyanoalkyl, heterocycle-bearing alkyl, haloalkyl, alkenyl, or alkynyl; A is alkylene bearing a carbon atom which two alkyl groups are bonded to and having 5 or more carbon atoms in total; and m is an integer of 1 to 3.