发明授权
- 专利标题: MONOFLUOROALKYL DERIVATIVES
- 专利标题(中): MONOFLUORALKYLDERIVATE
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申请号: EP00923110.1申请日: 2000-04-17
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公开(公告)号: EP1183232B1公开(公告)日: 2007-10-03
- 发明人: BENDER, David, Michael , CANTRELL, Buddy, Eugene , FRAY, Andrew, Hendley , JONES, Winton, Dennis , MILLER, William, David , MITCHELL, David , SIMON, Richard, Lee , ZARRINMAYEH, Hamideh , ZIMMERMAN, Dennis, Michael
- 申请人: ELI LILLY AND COMPANY
- 申请人地址: Lilly Corporate Center Indianapolis, Indiana 46285 US
- 专利权人: ELI LILLY AND COMPANY
- 当前专利权人: ELI LILLY AND COMPANY
- 当前专利权人地址: Lilly Corporate Center Indianapolis, Indiana 46285 US
- 代理机构: Suarez-Miles, Ana Sanchiz
- 优先权: US131771P 19990430; US177566P 20000121
- 国际公布: WO2000066546 20001109
- 主分类号: C07C311/03
- IPC分类号: C07C311/03 ; C07C311/04 ; C07C311/06 ; C07C311/05 ; C07C311/08 ; C07D333/20 ; C07D213/81 ; C07D213/82 ; C07C311/37 ; A61K31/18 ; A61K31/44 ; A61K31/38
摘要:
The present invention provides monofluoroalkyl derivatives of the formula (I) wherein: A represents SO2, CO2 or CONH; Ra represents (1-6C)alkyl, (2-6C)alkenyl, -(1-4C)alkyl(3-8C)cycloalkyl, or (1-4C)alkylaromatic; Rb represents H, (1-6C)alkyl, (2-6C)alkenyl, -(1-4C)alkyl(3-8C)cycloalkyl, or (1-4C)alkylaromatic; or R?a and Rb¿ together with the carbon atoms to which they are attached form a (3-8C) saturated carbocyclic ring, a (3-8C) saturated carbocyclic ring containing a heteroatom selected from the group consisting of sulfur or oxygen, or a (5-8C) carbocyclic ring containing one double bond; R1 represents an unsubstituted or substituted aromatic group, an unsubstituted or substituted heteroaromatic group, or an unsubstituted or substituted (5-8C)cycloalkyl group; R2 represents (1-6C)alkyl, (3-6C)cycloalkyl, (1-6C)fluoroalkyl, (1-6C)chloroalkyl, (2-6C)alkenyl, (1-4C)alkoxy(1-4C)alkyl, phenyl which is unsubstituted or substituted by halogen, (1-4C)alkyl or (1-4C)alkoxy, or when A represents SO¿2?, a group of formula R?3R4¿N in which R?3 and R4¿ each independently represents (1-4C)alkyl or , together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; or a pharmaceutically acceptable salt thereof, useful for potentiating glutamate receptor function in a mammal and thereof, useful for treating a wide variety of condutions, such as psychiatric and neurological disorder.
公开/授权文献
- EP1183232A2 MONOFLUOROALKYL DERIVATIVES 公开/授权日:2002-03-06
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