发明授权
- 专利标题： ALPHA V INTEGRIN RECEPTOR ANTAGONISTS
- 专利标题（中）： ALPHAαv整受体拮抗剂
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申请号： EP00942652.9申请日： 2000-05-30
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公开(公告)号： EP1187592B1公开(公告)日： 2007-08-01
- 发明人: COLEMAN, Paul, J. , DUGGAN, Mark, E. , HALCZENKO, Wasyl , HARTMAN, George, D. , HUTCHINSON, John, H. , MEISSNER, Robert, S. , PATANE, Michael, A. , PERKINS, James, J. , WANG, Jiabing , BRESLIN, Michael, J.
- 申请人： Merck & Co., Inc.
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 代理机构： Horgan, James Michael Frederic
- 优先权： US137101P 19990602; US179216P 20000131
- 国际公布： WO2000072801 20001207
- 主分类号： A61K31/506
- IPC分类号： A61K31/506 ; C07D239/48 ; C07D401/06 ; C07D471/04 ; A61K31/4375 ; A61K31/55 ; C07D519/00 ; A61P19/10
摘要：
The present invention relates to novel nonanoic acid derivatives, their synthesis, and their use as alphaV integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alphaV beta3 and alphaV beta5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, inflammatory arthritis, viral disease, cancer, and metastatic tumor growth.
公开/授权文献
- EP1187592A2 ALPHA V INTEGRIN RECEPTOR ANTAGONISTS 公开/授权日：2002-03-20
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