发明公开
- 专利标题： AMINOBENZOIC ACID DERIVATIVES
- 专利标题（中）： AMINOBENZOESÄURE衍
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申请号： EP00940927申请日： 2000-07-03
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公开(公告)号： EP1193246A4公开(公告)日： 2003-05-14
- 发明人: WADA HISAYA , ASANUMA HAJIME , TAKAYAMA TETSUO , SATO MASAKAZU , YAMAGISHI TAKEHIRO , SHIBUYA MASABUMI
- 申请人： TAISHO PHARMA CO LTD
- 专利权人： TAISHO PHARMA CO LTD
- 当前专利权人： TAISHO PHARMA CO LTD
- 优先权： JP18827199 1999-07-01; JP18827299 1999-07-01
- 主分类号： A61P43/00
- IPC分类号： A61P43/00 ; C07C235/24 ; C07C235/38 ; C07C317/50 ; C07C323/63 ; C07D213/80 ; A61K31/196
摘要：
Aminobenzoic acid derivatives represented by general formula (1) or pharmaceutically acceptable salts thereof which are usable as VEGF receptor antagonists, in particular, remedies for diseases in which VEGF participates wherein R1 represents hydrogen, C¿1-6? alkyl, etc.; R?2¿ represents hydrogen, C¿1-6? alkyl, etc.; R?3¿ represents C¿8-25? alkyl, etc.; R?4¿ represents hydrogen, OR9 or CO¿2R?10 (wherein R?9 and R10¿ represent each hydrogen or C¿1-6? alkyl); A represents S(O)qR?15¿ [wherein q is 0, 1 or 2; and R15 represents C¿1-6? alkyl, phenyl (C1-3 alkyl) or (CH2)mOR?16¿ (wherein m is 2 or 3; and R16 represents hydrogen or methoxymethyl)], etc.; X represents O, a single bond, CH=CH or NR27 (wherein R27 represents hydrogen or t-butoxycarbonyl); Y represents O, CONH, NHCO or NR28 (wherein R28 represents hydrogen or t-butoxycarbonyl); and n is an integer of from 0 to 15.
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