发明公开
- 专利标题： GLOBULAR ASSEMBLY OF AMYLOID BETA PROTEIN AND USES THEREOF
- 专利标题（中）： β淀粉样蛋白的球状建筑及其用途
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申请号： EP00952571.8申请日： 2000-08-04
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公开(公告)号： EP1200470A2公开(公告)日： 2002-05-02
- 发明人: KRAFFT, Grant, A. , KLEIN, William, L. , CHROMY, Brett, A. , LAMBERT, Mary, P. , FINCH, Caleb, E. , MORGAN, Todd , WALS, Pat , ROZOVSKY, Irina , BARLOW, Ann
- 申请人： THE UNIVERSITY OF SOUTHERN CALIFORNIA , NORTHWESTERN UNIVERSITY
- 申请人地址： University Park Los Angeles,California 90089 US
- 专利权人： THE UNIVERSITY OF SOUTHERN CALIFORNIA,NORTHWESTERN UNIVERSITY
- 当前专利权人： THE UNIVERSITY OF SOUTHERN CALIFORNIA,NORTHWESTERN UNIVERSITY
- 当前专利权人地址： University Park Los Angeles,California 90089 US
- 代理机构： Brown, John David
- 优先权： US369236 19990804
- 国际公布： WO0110900 20010215
- 主分类号： C07K14/47
- IPC分类号： C07K14/47 ; G01N33/68 ; A61K38/04
摘要：
The invention provides amyloid beta-derived dementing ligands (ADDLs) that comprise amyloid β protein assembled into globular non-fibrillar oligomeric structures capable of activating specific cellular processes. The invention also provides methods for assaying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDLs, and modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders.
公开/授权文献
- EP1200470B1 GLOBULAR ASSEMBLY OF AMYLOID BETA PROTEIN AND USES THEREOF 公开/授权日：2004-11-24
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