发明公开
EP1200601A1 VERFAHREN ZUR HERSTELLUNG VON L-AMINOSÄUREN AUS IHREN RACEMISCHEN N-ACETYL-D,L-DERIVATEN DURCH ENZYMATISCHE RACEMAT-SPALTUNG MITTELS ISOLIERTER, REKOMBINANTER ENZYME
有权
用于生产L-氨基酸FROM YOUR RACE MIX N-乙酰基-D，L-衍生物BY酶法拆分SPLIT BY分离的，重组酶
- 专利标题： VERFAHREN ZUR HERSTELLUNG VON L-AMINOSÄUREN AUS IHREN RACEMISCHEN N-ACETYL-D,L-DERIVATEN DURCH ENZYMATISCHE RACEMAT-SPALTUNG MITTELS ISOLIERTER, REKOMBINANTER ENZYME
- 专利标题（英）： Method for the production of l-amino acids from their racemic n-acetyl-d, l-derivatives by enzymatic racemate cleavage by means of isolated recombinant enzymes
- 专利标题（中）： 用于生产L-氨基酸FROM YOUR RACE MIX N-乙酰基-D，L-衍生物BY酶法拆分SPLIT BY分离的，重组酶
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申请号： EP00943826.8申请日： 2000-06-17
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公开(公告)号： EP1200601A1公开(公告)日： 2002-05-02
- 发明人: BARTSCH, Klaus
- 申请人： Aventis CropScience GmbH
- 申请人地址： Brüningstrasse 50 65929 Frankfurt am Main DE
- 专利权人： Aventis CropScience GmbH
- 当前专利权人： Aventis CropScience GmbH
- 当前专利权人地址： Brüningstrasse 50 65929 Frankfurt am Main DE
- 优先权： DE19933362 19990720
- 国际公布： WO0105982 20010125
- 主分类号： C12N15/55
- IPC分类号： C12N15/55 ; C12N11/08 ; C12N9/80 ; C12P41/00 ; C12P13/04
摘要：
The invention relates to a method for the production of proteinogenic or non-proteinogenic L-amino acids, especially L-phosphinothricin, from their racemic N-acetyl-D,L-derivatives. The method is characterized in that: (a) N-acetyl-L-derivatives of the corresponding L-amino acids are selectively deacetylated by enzymatic racemate cleavage by means of isolated recombinant enzymes while the N-acetyl-D-derivatives of the corresponding D-amino acids are not deacetylated and (b) the deacetylated L-amino acids are preparatively separated from the non-deacetylated N-acetyl-D-derivatives and/or the incompletely deacetylated N-acetyl-L-derivatives.
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