发明公开
- 专利标题： NEUE ANTAGONISTEN VON INTEGRINREZEPTOREN
- 专利标题（英）： Novel integrin receptor antagonists
- 专利标题（中）： 整合的新拮抗剂
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申请号： EP00958347.7申请日： 2000-08-01
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公开(公告)号： EP1202988A2公开(公告)日： 2002-05-08
- 发明人: KLING, Andreas , GENESTE, Hervé , LANGE, Udo , LAUTERBACH, Arnulf , GRAEF, Claudia, Isabella , SUBKOWSKI, Thomas , HOLZENKAMP, Uta , MACK, Helmut , SADOWSKI, Jens , HORNBERGER, Wilfried , LAUX, Volker
- 申请人： BASF AKTIENGESELLSCHAFT
- 申请人地址： 67056 Ludwigshafen DE
- 专利权人： BASF AKTIENGESELLSCHAFT
- 当前专利权人： BASF AKTIENGESELLSCHAFT
- 当前专利权人地址： 67056 Ludwigshafen DE
- 代理机构： Grünecker, Kinkeldey, Stockmair & SchwanhäusserAnwaltssozietät
- 优先权： DE19936780 19990809
- 国际公布： WO0110847 20010215
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; A61K31/55 ; A61P43/00 ; C07D401/14 ; C07D213/73 ; C07D403/12 ; C07D491/04 ; C07D409/14
摘要：
The invention relates to novel compounds of formula (I) which bind to integrin receptors, wherein G and L have the following meaning: L is a structural element of formula IL, wherein T represents a COOH group or a radical that can be hydrolyzed to obtain COOH and U- represents (XL)a-(CRL1RL2)b-, -CR¿L?1=CRL2-, ethylene or =CR¿L?1-, wherein a is 0 or 1; b is 0, 1 or 2; X¿L? represents CRL?3R¿L4, NRL5, oxygen or sulfur and G is a structural element of formula I¿G?, wherein the insertion of structural element G can occur in both orientations and XO represents nitrogen or CRG?1¿. The invention also relates to the production of said compounds and to their use as medicaments.
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