发明公开
- 专利标题： METHODS OF OBTAINING 2-METHOXYESTRADIOL OF HIGH PURITY
- 专利标题（中）： 获得高纯度2-甲氧基二醇的方法
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申请号： EP00964915.3申请日： 2000-08-23
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公开(公告)号： EP1206480A2公开(公告)日： 2002-05-22
- 发明人: AGOSTON, Gregory, E. , TRESTON, Anthony, M. , SHAH, Jamshed, H.
- 申请人： EntreMed, Inc.
- 申请人地址： 9640 Medical Center Drive Rockville, MD 20850 US
- 专利权人： EntreMed, Inc.
- 当前专利权人： EntreMed, Inc.
- 当前专利权人地址： 9640 Medical Center Drive Rockville, MD 20850 US
- 代理机构： Boulinguiez, Didier
- 优先权： US150293P 19990823
- 国际公布： WO0114405 20010301
- 主分类号： C07J1/00
- IPC分类号： C07J1/00
摘要：
2-methoxyestradiol having greater than 98% purity is obtained by synthetic or purification methods. This highly pure 2-methoxy estradiol, lacking estrogenic components, is particularly suitable for clinical use in humans. The purification methods of the invention involve the use of liquid-solid chromatography (LSC) to separate 2-ME2 from other compounds. The chromatographic media is preferably silica. The solvent system comprises a non-polar solvent, such as chloroform, and a polar solvent, such as methanol.
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