发明公开
EP1208086A1 BENZAMIDE FORMULATION WITH HISTONE DEACETYLASE INHIBITOR ACTIVITY
有权
组蛋白去乙酰化酶抑制剂活性BENZAMIDFORMULIERUNG
- 专利标题: BENZAMIDE FORMULATION WITH HISTONE DEACETYLASE INHIBITOR ACTIVITY
- 专利标题(中): 组蛋白去乙酰化酶抑制剂活性BENZAMIDFORMULIERUNG
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申请号: EP00956496.4申请日: 2000-08-29
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公开(公告)号: EP1208086A1公开(公告)日: 2002-05-29
- 发明人: ISHIBASHI, Masahiko , SAKABE, Masahiro , SAKAI, Ikuo , SUZUKI, Tsuneji , ANDO, Tomoyuki
- 申请人: SCHERING AKTIENGESELLSCHAFT
- 申请人地址: Müllerstrasse 170/178 13353 Berlin DE
- 专利权人: SCHERING AKTIENGESELLSCHAFT
- 当前专利权人: SCHERING AKTIENGESELLSCHAFT
- 当前专利权人地址: Müllerstrasse 170/178 13353 Berlin DE
- 代理机构: Dörries, Hans Ulrich, Dr.
- 优先权: JP24244499 19990830
- 国际公布: WO0116106 20010308
- 主分类号: C07D213/30
- IPC分类号: C07D213/30 ; C07D213/75 ; C07D213/65 ; A61K31/4406 ; A61P35/00
摘要:
There are provided pharmaceutical formulations with improved oral absorptivity and injections that contain, as active ingredients, high concentrations of benzamide derivatives and their pharmaceutically acceptable salts, which are useful as histone deacetylase inhibitors. A pharmaceutical solution is prepared by dissolving a benzamide derivative or a pharmaceutically acceptable salt thereof in an organic solvent and/or acidic liquid, and a pharmaceutical formulation is prepared by adding a surfactant, an acidic substance and/or a polyethylene glycol. The present invention has enabled dissolution of benzamide derivatives or their pharmaceutically acceptable salts at high concentrations, to prepare practical injections and oral liquid formulations and improve absorptivity with oral administration.
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