发明公开
EP1210320A1 AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA
有权
作为IL-1BETA和TNF-α的抑制剂的氨基苯并EN酮
- 专利标题: AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA
- 专利标题(中): 作为IL-1BETA和TNF-α的抑制剂的氨基苯并EN酮
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申请号: EP00943699.9申请日: 2000-07-11
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公开(公告)号: EP1210320A1公开(公告)日: 2002-06-05
- 发明人: OTTOSEN, Erik, Rytter
- 申请人: LEO PHARMACEUTICAL PRODUCTS LTD. A/S(LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB)
- 申请人地址: Industriparken 55 2750 Ballerup DK
- 专利权人: LEO PHARMACEUTICAL PRODUCTS LTD. A/S(LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB)
- 当前专利权人: LEO PHARMACEUTICAL PRODUCTS LTD. A/S(LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB)
- 当前专利权人地址: Industriparken 55 2750 Ballerup DK
- 代理机构: Thalsoe-Madsen, Kine Birgit
- 优先权: US144166P 19990716
- 国际公布: WO0105746 20010125
- 主分类号: C07C235/04
- IPC分类号: C07C235/04 ; C07C237/04 ; C07C229/18 ; A61K31/165 ; A61K31/222
摘要:
The present invention relates to a compound of general formula (I) wherein R1, R2, and R3 represents one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkyl, (C2-C3)olefinic group, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, cyano, -CONH2, phenyl, or nitro; further R2 can be hydrogen, and R3 can be carboxy and carbamoyl; R4 represents hydrogen, (C1-C3)alkyl, or allyl; X represents oxygen or sulphur; Q represents -(CO)-, -(CS)-, or a bond; Y represents (C5-C15)alkyl; (C2-C15)olefinic group; (C3-C10)monocyclic hydrocarbon group; or phenyl; any of which may be optionally substituted by one or more, same or different substituents selected from the group consisting of the formula R5 defined below; (C1-C4)alkyl substituted by one or more substituents selected for the group R5; or a group of the formula -(Z-O)n-Z, wherein Z is a (C1-C3)alkyl, n is an integer > 1; and no continuous linear sequence of atoms in the group Y exceeds 15; R5 represents halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkoxy, (C1-C3)alkylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, cyano, azido, nitro, -COOH, -CONH2, -CONHR', or COONR'R' wherein R' represents (C1-C3)alkyl; or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof. The compounds are valuable in the human and veterinary therapy.
公开/授权文献
- EP1210320B1 AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA 公开/授权日:2004-09-29
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