发明公开
EP1212296A1 PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS
有权
PHOSPHAT-MIMETIKA SOWIE BEHANDLUNGSMETHODEN UNTER VERWENDUNG VON PHOSPHATASE-INHIBITOREN
- 专利标题： PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS
- 专利标题（中）： PHOSPHAT-MIMETIKA SOWIE BEHANDLUNGSMETHODEN UNTER VERWENDUNG VON PHOSPHATASE-INHIBITOREN
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申请号： EP00961360.5申请日： 2000-08-25
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公开(公告)号： EP1212296A1公开(公告)日： 2002-06-12
- 发明人: HUANG, Ping , WEI, Chung, Chen , TANG, Peng, Cho , LIANG, Chris , RAMPHAL, John , JALLAL, Bahija , BILTZ, John , LI, Sharon , MATTSON, Matthew, Neil , MCMAHON, Gerald , KOENIG, Marcel
- 申请人： Sugen, Inc.
- 申请人地址： 230 East Grand Avenue South San Francisco, CA 94080-4811 US
- 专利权人： Sugen, Inc.
- 当前专利权人： Sugen, Inc.
- 当前专利权人地址： 230 East Grand Avenue South San Francisco, CA 94080-4811 US
- 代理机构： Viering, Hans-Martin, Dipl.-Ing.
- 优先权： US150970P 19990827; US165365P 19991112
- 国际公布： WO0116097 20010308
- 主分类号： C07C317/14
- IPC分类号： C07C317/14 ; C07C311/09 ; C07D231/24 ; C07D235/16 ; C07D235/18 ; C07D295/096 ; C07D209/42 ; A61K31/10 ; A61K31/18 ; A61K31/415 ; A61K31/535 ; A61K31/416 ; A61K31/404
摘要：
The invention relates to trifluoromethyl sulfonyl and trifluoromethyl sulfonamido compounds and the physiologically acceptable salts and the prodrugs thereof. These compounds are expected to modulate the activity of protein tyrosine enzymes which are related to cellular signal transduction, in particular, protein tyrosine phosphatase, and therefore are expected to be useful in the prevention and treatment of disorders associated with abnormal protein tyrosine enzyme related cellular signal transduction such as cancer, diabetes, immuno-modulation, neurologic degenerative diseases, osteoporosis and infectious diseases. The invention also relates to the use of compounds containing fluoromethyl sulfonyl groups as phosphate mimics. These mimics may be used to inhibit, regulate or modulate the activity of a phosphate binding protein in a cell.
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