发明公开
EP1214060A2 METHOD OF INHIBITING PROTEIN TYROSINE PHOSPHATASE 1B AND/OR T-CELL PROTEIN TYROSINE PHOSPHATASE AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48
审中-公开
用于抑制TYROSINPHOPHATASE 1B和/或T细胞蛋白TYRONSINPHOSPHATASE WITH A ASP REST在4位和/或其他的PTPases
- 专利标题： METHOD OF INHIBITING PROTEIN TYROSINE PHOSPHATASE 1B AND/OR T-CELL PROTEIN TYROSINE PHOSPHATASE AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48
- 专利标题（中）： 用于抑制TYROSINPHOPHATASE 1B和/或T细胞蛋白TYRONSINPHOSPHATASE WITH A ASP REST在4位和/或其他的PTPases
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申请号： EP00963340.5申请日： 2000-09-11
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公开(公告)号： EP1214060A2公开(公告)日： 2002-06-19
- 发明人: ANDERSEN, Henrik, Sune , HANSEN, Thomas, Kruse , Iverson, Lars Fogh , LAU, Jesper , M LLER, Niels, Peter, Hundahl , OLSEN, Ole, Hvilsted , AXE, Frank, Urban , GE, Yu , HOLSWORTH, Daniel, Dale , JONES, Todd, Kevin , JUDGE, Luke, Milburn , RIPKA, William, Charles , SHAPIRA, Barry, Zvi , UYEDA, Roy Teruyuki
- 申请人： NOVO NORDISK A/S , Ontogen Corporation
- 申请人地址： Novo Allé 2880 Bagsvaerd DK
- 专利权人： NOVO NORDISK A/S,Ontogen Corporation
- 当前专利权人： NOVO NORDISK A/S,Ontogen Corporation
- 当前专利权人地址： Novo Allé 2880 Bagsvaerd DK
- 优先权： DK127999 19990910; US156641P 19990929
- 国际公布： WO0117516 20010315
- 主分类号： A61K31/00
- IPC分类号： A61K31/00 ; A61K31/435 ; A61K31/381 ; A61K31/38
摘要：
The present invention provides a method of inhibiting a member of a family of Protein Tyrosine Phosphatases (PTPases, PTPs) such as PTP1B, TC-PTP, CD45, SHP-1, SHP-2, PTPα, PTPε, PTPν, PTPδ, PTPσ, PTPz, PTPβ, PTPD1, PTPD2, PTPH1, PTP-MEG1, PTP-LAR, and HePTP by exposing said Ptpase member by administration to a host or otherwise to at least one compound with certain structural, physical and spatial characteristics that allow for the interaction of said compound with specific residues of the active site of PTP1B and/or TC-PTP. These compounds are indicated in the management or treatment of a broad range of diseases such as autoimmune diseases, acute and chronic inflammation, osteoporosis, various forms of cancer and malignant diseases, and type I diabetes and type II diabetes, as well as in the isolation of PTPases and in elucidation or further elucidation of their biological function.
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