发明公开
- 专利标题: RIBOZYME ZUR RESTENOSE-PRÄVENTION
- 专利标题(英): Ribozymes used for restenosis prevention
- 专利标题(中): 核酶预防再狭窄
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申请号: EP99948829.9申请日: 1999-09-22
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公开(公告)号: EP1214408A1公开(公告)日: 2002-06-19
- 发明人: GRASSI, Gabriele , KUHN, Anne, Christine , KANDOLF, Reinhard
- 申请人: Eberhard-Karls-Universität Tübingen Universitätsklinikum
- 申请人地址: Geissweg 3 72076 Tübingen DE
- 专利权人: Eberhard-Karls-Universität Tübingen Universitätsklinikum
- 当前专利权人: Eberhard-Karls-Universität Tübingen Universitätsklinikum
- 当前专利权人地址: Geissweg 3 72076 Tübingen DE
- 代理机构: Otten, Hajo, Dr.-Ing.
- 国际公布: WO0121789 20010329
- 主分类号: C12N15/11
- IPC分类号: C12N15/11 ; C12N9/00 ; C12N15/86 ; A61K31/713 ; A61K48/00
摘要:
The invention relates to a catalytically active RNA molecule that is directed to mRNA molecules that encode the cell cycle relevant proteins cyclin E or E2F1. The catalytically active RNA molecule is a hammerhead ribozyme that induces the inhibition of the cell cycle of vascular smooth muscle cells in order to prevent restenosis.
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