发明公开
EP1218379A2 CERTAIN ALKYLENE DIAMINE-SUBSTITUTED PYRAZOLO 1,5,-a]-1,5-PYRIMIDINES AND PYRAZOLO 1,5-a]-1,3,5-TRIAZINES
审中-公开
一些取代的亚烷基-APYRAZOLO¬1,5-1,5-嘧啶和PYRAZOLO¬1,5-A -1,3,5-三嗪
- 专利标题： CERTAIN ALKYLENE DIAMINE-SUBSTITUTED PYRAZOLO 1,5,-a]-1,5-PYRIMIDINES AND PYRAZOLO 1,5-a]-1,3,5-TRIAZINES
- 专利标题（中）： 一些取代的亚烷基-APYRAZOLO¬1,5-1,5-嘧啶和PYRAZOLO¬1,5-A -1,3,5-三嗪
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申请号： EP00967134.8申请日： 2000-09-29
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公开(公告)号： EP1218379A2公开(公告)日： 2002-07-03
- 发明人: DARROW, James, W. , DE LOMBAERT, Stephane , BLUM, Charles , TRAN, Jennifer , GIANGIORDANO, Mark , GRIFFITH, David, Andrew , CARPINO, Philip, Albert
- 申请人： NEUROGEN CORPORATION , PFIZER INC.
- 申请人地址： 35 N.E. Industrial Road Branford, CT 06405 US
- 专利权人： NEUROGEN CORPORATION,PFIZER INC.
- 当前专利权人： NEUROGEN CORPORATION,PFIZER INC.
- 当前专利权人地址： 35 N.E. Industrial Road Branford, CT 06405 US
- 代理机构： Ebner von Eschenbach, Jennifer
- 优先权： US156869P 19990930
- 国际公布： WO0123387 20010405
- 主分类号： C07D487/00
- IPC分类号： C07D487/00 ; A61K31/53 ; A61K31/519 ; A61P9/00 ; A61P25/00 ; G01N33/566
摘要：
Disclosed are compounds of formula (I), where R?1, R2, R3, R4, R5, R6¿, and X are defined herein. These compounds are selective modulators of NPY1 receptors. These compounds are useful in the treatment of a number of CNS disorders, metabolic disorders, and peripheral disorders, particularly eating disorders and hypertension. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of NPY1 receptors and as standards in assays for NPY1 receptor binding. Methods of using the compounds in receptor localization studies are given.
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