发明公开
EP1218390A2 CHROMOGENIC SUBSTRATES OF SIALIDASE OF BACTERIAL, VIRAL, PROTOZOA, AND VERTEBRATE ORIGIN AND METHODS OF MAKING AND USING THE SAME
审中-公开
显色底物为细菌，病毒，原生动物和椎产地，其生产和使用唾液酸酶
- 专利标题： CHROMOGENIC SUBSTRATES OF SIALIDASE OF BACTERIAL, VIRAL, PROTOZOA, AND VERTEBRATE ORIGIN AND METHODS OF MAKING AND USING THE SAME
- 专利标题（中）： 显色底物为细菌，病毒，原生动物和椎产地，其生产和使用唾液酸酶
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申请号： EP00975221.3申请日： 2000-10-05
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公开(公告)号： EP1218390A2公开(公告)日： 2002-07-03
- 发明人: JOHNSON, Stephen, C. , LUO, Ming , YAN, Shijia
- 申请人： Ibbex, Inc. , THE UAB RESEARCH FOUNDATION
- 申请人地址： Suite 373,2800 Milan Court Birmingham, AL 35211 US
- 专利权人： Ibbex, Inc.,THE UAB RESEARCH FOUNDATION
- 当前专利权人： Ibbex, Inc.,THE UAB RESEARCH FOUNDATION
- 当前专利权人地址： Suite 373,2800 Milan Court Birmingham, AL 35211 US
- 代理机构： Perry, Robert Edward
- 优先权： US412896 19991005
- 国际公布： WO0125246 20010412
- 主分类号： C07H15/203
- IPC分类号： C07H15/203 ; C07H15/26 ; C07H17/02 ; C07H17/075 ; C12Q1/34 ; C12N9/24
摘要：
The current invention relates to the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including human) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.
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