发明公开
EP1218753A2 THROMBOTIC EPISODE RISK ASSAYS USING OXIDIZED PHOSPHOLIPIDS
审中-公开
血栓形成风险EPISODE规则中使用的氧化磷脂
- 专利标题： THROMBOTIC EPISODE RISK ASSAYS USING OXIDIZED PHOSPHOLIPIDS
- 专利标题（中）： 血栓形成风险EPISODE规则中使用的氧化磷脂
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申请号： EP00965455.9申请日： 2000-09-26
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公开(公告)号： EP1218753A2公开(公告)日： 2002-07-03
- 发明人: ESMON, Naomi, L. , SAFA JAMILABADI, Omid
- 申请人： Oklahoma Medical Research Foundation
- 申请人地址： 825 N.E. 13th Street Oklahoma CityOklahoma 73104 US
- 专利权人： Oklahoma Medical Research Foundation
- 当前专利权人： Oklahoma Medical Research Foundation
- 当前专利权人地址： 825 N.E. 13th Street Oklahoma CityOklahoma 73104 US
- 代理机构： UEXKÜLL & STOLBERG
- 优先权： US156564P 19990928
- 国际公布： WO0123895 20010405
- 主分类号： G01N33/86
- IPC分类号： G01N33/86
摘要：
An assay to assess thrombotic risk in which oxidized lipids comprising phospholipids are utilized as a membrane source in a clotting assay and the results compared to an assay in which unoxidized phospholipid is used as a membrane source in the presence and absence of activated protein C ('APC'). The assay can monitor for the presence of antibodies in the patient which interfere specifically with the anticoagulant function of APC in an oxidation dependent or independent manner. This can indicate the propensity of the patient to experience episodes of vein thrombosis or arterial thrombosis.
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