发明公开
- 专利标题： MELANIN CONCENTRATING HORMONE ANTAGONISTS
- 专利标题（中）： 亵渎美人鱼芬兰
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申请号： EP00961076.7申请日： 2000-09-19
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公开(公告)号： EP1219294A1公开(公告)日： 2002-07-03
- 发明人: KATO, Kaneyoshi , MORI, Masaaki , SUZUKI, Nobuhiro , SHIMOMURA, Yukio Takeda Yakuhin Matsushiro Res.410 , TAKEKAWA, Shiro , CHOH, Nobuo
- 申请人： Takeda Chemical Industries, Ltd.
- 申请人地址： 1-1 Doshomachi 4-chome, Chuo-ku Osaka-shi, Osaka 541-0045 JP
- 专利权人： Takeda Chemical Industries, Ltd.
- 当前专利权人： Takeda Chemical Industries, Ltd.
- 当前专利权人地址： 1-1 Doshomachi 4-chome, Chuo-ku Osaka-shi, Osaka 541-0045 JP
- 代理机构： Lewin, John Harvey
- 优先权： JP26627899 19990920; JP2000221055 20000717
- 国际公布： WO0121169 20010329
- 主分类号： A61K31/137
- IPC分类号： A61K31/137 ; A61K31/27 ; A61K31/4035 ; A61K31/44 ; A61K31/445 ; A61K31/4453 ; A61K31/472 ; A61P43/00 ; A61P31/04 ; C07D211/14 ; C07D211/18 ; C07D211/46 ; C07D211/58 ; C07D211/70 ; C07D401/12 ; C07D405/12 ; C07D409/12 ; C07D417/12
摘要：
A compound represented by the formula
wherein Ar 1 and Ar 2 are each an aromatic group optionally having substituents, P and Q are each a divalent aliphatic hydrocarbon group which optionally contains ether oxygen or ether sulfur in a carbon chain and which optionally has substituents, R 1 and R 3 are each (i) a hydrogen atom, (ii) an acyl group or (iii) an hydrocarbon group optionally having substituents, R 2 and R 4 are each (i) a hydrogen atom, (ii) an alkyl group optionally having substituents or (iii) an alkylcarbonyl optionally having substituents, R 1 and R 2 or R 3 and R 4 each optionally forms, together with the adjacent nitrogen atom, a monocyclic or fused nitrogen-containing heterocyclic group optionally having substituents, j is 0 or 1, a salt thereof or a prodrug thereof are useful as melanin-concentrating hormone antagonists.
wherein Ar 1 and Ar 2 are each an aromatic group optionally having substituents, P and Q are each a divalent aliphatic hydrocarbon group which optionally contains ether oxygen or ether sulfur in a carbon chain and which optionally has substituents, R 1 and R 3 are each (i) a hydrogen atom, (ii) an acyl group or (iii) an hydrocarbon group optionally having substituents, R 2 and R 4 are each (i) a hydrogen atom, (ii) an alkyl group optionally having substituents or (iii) an alkylcarbonyl optionally having substituents, R 1 and R 2 or R 3 and R 4 each optionally forms, together with the adjacent nitrogen atom, a monocyclic or fused nitrogen-containing heterocyclic group optionally having substituents, j is 0 or 1, a salt thereof or a prodrug thereof are useful as melanin-concentrating hormone antagonists.
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